Skip to main content

New method to make lung cancer drug trials more successful

Australian researchers have developed a new method for finding participants in clinical trials of lung cancer drugs, it was announced on Wednesday.

Researchers from Melbourne's Walter and Eliza Hall Institute (WEHI) were optimistic that the new recruitment process will boost the success rate of drugs being trialled as treatments for lung squamous cell carcinoma, the second most common type of lung cancer.

By mimicking the complexity of human tumours with a research tool, the scientists were able to identify a "biomarker" which could serve as an indication as to which patients would better respond to certain drugs, Xinhua news agency reported.

Marie-Liesse Asselin-Labat, the lead author of the study, said patients with the biomarker were more likely to respond positively to fibroglast growth factor receptor (FGFR) drugs.

"We found that high levels of the anti-cancer drug's target, FGFR1, in a patient's tumour ribonucleic acid (RNA) were a better predictor of their potential response to the drug than the current tests that are used," Asselin-Labat said on Wednesday.

Ben Solomon, a medical oncologist from the Peter MacCallum Cancer Centre, said the finding meant future clinical trials could be designed to succeed.

"Fewer than 10 per cent of new cancer drugs make it past phase 1 clinical trials. In many cases this isn't because of the drug itself, but because of a limitation in clinical trial design," Solomon said.

"Understanding which patients are most likely to respond to certain drugs in clinical trials is crucial both for patients to receive the best treatment, and for new drugs to make it to the clinic."

"Hopefully these data will help to improve trial outcomes by recruiting patients who otherwise might not have been matched to the right trial for them," Solomon said.



Comments

Popular posts from this blog

FDA Restricts Use of Diabetes Drug Avandia

FDA Decides Not to Ban Avandia, but Puts Restrictions on How It’s Used.
By Daniel J. DeNoon
WebMD Health News

Sept. 23, 2010 -- The FDA will not ban Avandia -- but stringent restrictions will make it far harder for doctors to prescribe the safety-troubled diabetes drug.

The European Medicines Agency took harsher action. European sales of Avandia-containing drugs will be suspended over the next few months, although the agency did not formally withdraw approval.

The 600,000 U.S. patients currently taking Avandia can continue to take the drug only if their doctors officially attest that their patients understand the risks, that the drug is helping them, and that no other diabetes drug can keep their blood sugar under control.

New Avandia prescriptions can only be written for patients who, for medical reasons, cannot take Actos. Actos, a diabetes medication in the same class as Avandia, does not cause the heart problems linked to Avandia.

"Avandia will be available to new pat…

Isotretinoin in India: A tragedy in the offing

Isotretinoin in India: A tragedy in the offing
Wednesday, March 28, 2007 08:00 IST 
Seema Thakral

Isotretinoin is the drug of choice for severe calcitrant cystic acne vulgaris, which often causes scarring and depression from disfigurement. Isotretinoin has been called "the greatest medical advance of the 1980's." A majority of patients with acne are permanently cleared after a four to five months course of treatment. It has also been used off-label for a variety of oncology uses including: cervical cancer, head and neck cancer, squamous cell cancer of the skin, juvenile chronic myelogenous leukemia (CML), and neuroblastoma. However, the drug is a proved teratogen and carries a significant risk of birth defects, if it taken during pregnancy. Birth defects, which have been documented following isotretinoin exposure include abnormalities of the face, eyes, ears, skull, central nervous system, cardiovascular system, and thymus and parathyroid glands. There is an increased risk …

The Influence of TheTourniquet on blood draw

[1] Various methods are used to obtain specimens for hematocritdetermination in neonates. We evaluated arterial sampling andfound this method to be acceptable. Arterial values correlatedclosely with simultaneously obtained venous samples. Venousblood obtained with a tourniquet had a significantly higherhematocrit than that obtained without a tourniquet.[2] Influence of tourniquet application on venous blood sampling for serum chemistry, hematological parameters, leukocyte activation and erythrocyte mechanical propertiesBackground: Venous blood sampling is usually performed using a tourniquet to help locate and define peripheral veins to achieve successful and safe venipuncture. Despite widespread usage of tourniquets for venipuncture by medical and laboratory staff, very few are aware of the effects of tourniquet application on laboratory parameters. In addition, definitive guidelines regarding when and how to use a tourniquet for blood sampling are lacking. The aim of the present stu…